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Article

Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia.

Antioxidants & redox signaling - 1 Oct 2011

Gysin René, Kraftsik Rudolf, Boulat Olivier, Bovet Pierre, Conus Philippe, Comte-Krieger Emily, Polari Andrea, Steullet Pascal, Preisig Martin, Teichmann Tanja, Cuénod Michel, Do Kim Q

Abstract excerpt

Genetic studies have shown an association between schizophrenia and a GAG trinucleotide repeat (TNR) polymorphism in the catalytic subunit (GCLC) of the glutamate cysteine ligase (GCL), the key enzyme for glutathione (GSH) synthesis. The present study was aimed at analyzing the influence of a GSH...

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Source

Identifiers

PMID: 20673128
DOI: 10.1089/ars.2010.3463

Genes

GCLC
TNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20673128-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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