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Article

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.

Experimental cell research - 1 Jan 2016

Hettmer Simone, Lin Michael M, Tchessalova Daria, Tortorici Sara J, Castiglioni Alessandra, Desai Tushar, Mao Junhao, McMahon Andrew P, Wagers Amy J

Abstract excerpt

Hedgehog (Hh) pathway activation in R26-SmoM2;CAGGS-CreER mice, which carry a tamoxifen-inducible activated Smoothened allele (SmoM2), results in numerous microscopic tumor foci in mouse skeletal muscle. These tumors exhibit a highly differentiated myogenic phenotype and resemble human fetal rhabdomyomas. This study sought to apply previously established strategies to isolate lineally distinct populations of...

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Identifiers

PMID: 26460176
DOI: 10.1016/j.yexcr.2015.10.008
PMCID: PMC4718790

Genes

PAX7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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