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Article

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

25 Feb 2009

Abstract excerpt

The Hedgehog (Hh) pathway has been implicated in pancreatic cancer but its role remains controversial. To delineate the cell populations able to respond to Hh ligand stimulation, we expressed an oncogenic allele of Smoothened (SmoM2) to cell autonomously activate Hh signaling in the mouse pancreas. Surprisingly, we found that expression of SmoM2 in epithelial cells was not able to activate the pathway and had no...

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PMID: 19246386
DOI: 10.1073/pnas.0813203106

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