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Article

Requirement of TGFβ Signaling for SMO-mediated Carcinogenesis

22 Sept 2010

Abstract excerpt

Hedgehog (Hh) signaling, via the key signal transducer Smoothened (SMO) and Gli transcription factors, is essential for embryonic development and carcinogenesis. At present, the molecular mechanism of Hh signaling-mediated carcinogenesis is not completely understood. Using a mouse model (K14cre/R26SmoM2) of SMO-mediated basal cell carcinoma development, we identified TGFβ2 as a major Hh-regulated gene. TGFβ2...

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PMID: 20858897
DOI: 10.1074/jbc.c110.164442

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