Article
Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats.
Immunobiology - 1 Jan 2007
Miletić Tatjana, Kovacević-Jovanović Vesna, Vujić Vesna, Stanojević Stanislava, Mitić Katarina, Lazarević-Macanović Mirjana, Dimitrijević Mirjana
Abstract excerpt
There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, recent research supports their role as signaling and regulatory molecules. In the present study...
Topics
- Animals
- Arthritis, Experimental
- Genetic Predisposition to Disease
- Male
- Nitric Oxide
- Rats
- Rats, Inbred Strains
- Reactive Oxygen Species
- Species Specificity
