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Article

Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer

1 Jan 2011

Abstract excerpt

Cancer cells exhibit two opposing methylation abnormalities: genome-wide hypomethylation and gene promoter hypermethylation. Downregulation of E-cadherin (CDH1) plays a key role in the development of diffuse-type gastric cancer, and DNA methylation is a major cause of the gene's silencing. Hereditary diffuse gastric cancer is caused by germline mutation of CDH1 gene, and DNA methylation frequently serves as the...

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PMID: 21273772
DOI: 10.1159/000320453

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