Article
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.
Molecular cell - 15 Feb 2008
Kurash Julia K, Lei Hong, Shen Qiong, Marston Wendy L, Granda Brian W, Fan Hong, Wall Daniel, Li En, Gaudet François
Abstract excerpt
The protein methyltransferase Set7/9 was recently shown to regulate p53 activity in cancer cells. However, the impact of Set7/9 on p53 function in vivo is unclear. To explore these issues, we created a null allele of Set7/9 in mice. Cells from Set7/9 mutant mice fail to methylate p53 K369, are unable to induce p53 downstream targets upon DNA damage, and are predisposed to oncogenic transformation. Importantly, we...
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