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Article

Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.

Molecular cell - 15 Feb 2008

Kurash Julia K, Lei Hong, Shen Qiong, Marston Wendy L, Granda Brian W, Fan Hong, Wall Daniel, Li En, Gaudet François

Abstract excerpt

The protein methyltransferase Set7/9 was recently shown to regulate p53 activity in cancer cells. However, the impact of Set7/9 on p53 function in vivo is unclear. To explore these issues, we created a null allele of Set7/9 in mice. Cells from Set7/9 mutant mice fail to methylate p53 K369, are un...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18280244
DOI: 10.1016/j.molcel.2007.12.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18280244-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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