Article
Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Jan 2011
Streltsov Victor A, Varghese Joseph N, Masters Colin L, Nuttall Stewart D
Abstract excerpt
Alzheimer's disease is a progressive neurodegenerative disorder associated with the presence of amyloid-β (Aβ) peptide fibrillar plaques in the brain. However, current evidence suggests that soluble nonfibrillar Aβ oligomers may be the major drivers of Aβ-mediated synaptic dysfunction. Structural information on these Aβ species has been very limited because of their noncrystalline and unstable nature. Here, we...
Topics
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Animals
- Crystallography, X-Ray
- Immunoglobulin Variable Region
- Models, Molecular
- Mutation
- Peptide Fragments
- Protein Multimerization
- Protein Structure, Quaternary
- Protein Structure, Secondary