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A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers

4 Apr 2018

Abstract excerpt

Oligomers of amyloid-β (AβO) are deemed key in synaptotoxicity and amyloid seeding of Alzheimer’s disease (AD). However, the heterogeneous and dynamic nature of AβO and inadequate markers for AβO subtypes have stymied effective AβO identification and therapeutic targeting in vivo . We identified an AβO-subclass epitope defined by differential solvent orientation of the lysine 28 side chain in a constrained loop...

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PMID: 29614860
DOI: 10.1021/acschemneuro.7b00469

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