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Article

An M2 cytoplasmic tail mutant as a live attenuated influenza vaccine against pandemic (H1N1) 2009 influenza virus.

Vaccine - 9 Mar 2011

Hatta Yasuko, Hatta Masato, Bilsel Pamuk, Neumann Gabriele, Kawaoka Yoshihiro

Abstract excerpt

The 2009 influenza pandemic brought home the importance of vaccines in infection control. Previously, we demonstrated an M2 cytoplasmic tail mutant H5N1 influenza virus could serve as a live-attenuated vaccine. Here, we adapted that strategy, generating a mutant pandemic (H1N1) 2009 virus that grew well in cell culture, but replicated less well in mice than did wild-type virus. The mutant virus elicited sterile...

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Source

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Identifiers

PMID: 21272601
DOI: 10.1016/j.vaccine.2011.01.023
PMCID: PMC3132197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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