Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for production of infectious virus particles.

doi:10.1128/JVI.00853-10

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Article

Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for production of infectious virus particles.

Journal of virology - 1 Sept 2010

Grantham Michael L, Stewart Shaun M, Lalime Erin N, Pekosz Andrew

Abstract excerpt

The cytoplasmic tail of the influenza A virus M2 protein is required for the production of infectious virions. In this study, critical residues in the M2 cytoplasmic tail were identified by single-alanine scanning mutagenesis. The tyrosine residue at position 76, which is conserved in >99% of influenza virus strains sequenced to date, was identified as being critical for the formation of infectious virus...

Topics

Amino Acid Motifs
Animals
Cell Line
Cricetinae
Humans
Influenza A virus
Influenza, Human
Mutation
Tyrosine
Viral Matrix Proteins
Virion
Virus Assembly
Virus Replication

Source

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Identifiers

PMID: 20573832
DOI: 10.1128/JVI.00853-10
PMCID: PMC2918991

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