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Article

Influenza A virus lacking M2 protein as a live attenuated vaccine.

Journal of virology - 1 Jun 2009

Watanabe Shinji, Watanabe Tokiko, Kawaoka Yoshihiro

Abstract excerpt

Mutant influenza virus that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) is attenuated in both cell culture and mice. Here, we examined the potency of M2KO influenza virus as a live attenuated influenza vaccine. M2KO virus grew as efficiently as the wild-type virus in cells stably expressing the wild-type M2, indicating the feasibility of efficient vaccine production. Mice...

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Identifiers

PMID: 19321619
DOI: 10.1128/JVI.00450-09
PMCID: PMC2681926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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