The cytoplasmic tail domain of influenza B virus hemagglutinin is important for its incorporation into virions but is not essential for virus replication in cell culture in the presence of compensatory mutations.

Abstract excerpt

Influenza B virus hemagglutinin (BHA) contains a predicted cytoplasmic tail of 10 amino acids that are highly conserved among influenza B viruses. To understand the role of this cytoplasmic tail in infectious virus production, we used reverse genetics to generate a recombinant influenza B virus lacking the BHA cytoplasmic tail domain. The resulting virus, designated BHATail(-), had a titer approximately 5 log...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hemagglutinin Glycoproteins, Influenza Virus
• Share to Influenza B virus