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Article

Cytoplasmic domain of CM2 is involved in the replication of influenza C virus.

The Journal of general virology - 1 Oct 2025

Shimotai Yoshitaka, Sugawara Kanetsu, Matsuzaki Yoko, Muraki Yasushi, Sho Ri, Goto Takanari, Hamamoto Hiroshi, Hongo Seiji

Abstract excerpt

CM2 is a single-pass transmembrane protein located in the viral envelope and is essential for the growth of influenza C virus. We previously reported that CM2 is involved in viral genome packaging and uncoating. We also demonstrated that alanine substitutions at residues 47-48, 67-69, 73-75, 85-87 and 113-115 in the cytoplasmic domain of CM2 significantly reduced its expression levels. Herein, we analysed whether...

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Identifiers

PMID: 41105524
DOI: 10.1099/jgv.0.002165
PMCID: PMC12534170

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