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Article

Pathological consequences of sequence duplications in the human genome.

Genome research - 1 Oct 1998

Mazzarella R, Schlessinger D

Abstract excerpt

As large-scale sequencing accumulates momentum, an increasing number of instances are being revealed in which genes or other relatively rare sequences are duplicated, either in tandem or at nearby locations. Such duplications are a source of considerable polymorphism in populations, and also increase the evolutionary possibilities for the coregulation of juxtaposed sequences. As a further consequence, they...

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PMID: 9799789
DOI: 10.1101/gr.8.10.1007

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