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Article

Transcriptional networks for alcohol sensitivity in Drosophila melanogaster.

Genetics - 1 Apr 2011

Morozova Tatiana V, Mackay Trudy F C, Anholt Robert R H

Abstract excerpt

Understanding the genetic architecture of polygenic traits requires investigating how complex networks of interacting molecules mediate the effect of genetic variation on organismal phenotypes. We used a combination of P-element mutagenesis and analysis of natural variation in gene expression to predict transcriptional networks that underlie alcohol sensitivity in Drosophila melanogaster. We identified 139 unique...

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Identifiers

PMID: 21270389
DOI: 10.1534/genetics.110.125229
PMCID: PMC3070527

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