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Article

Alcohol sensitivity in Drosophila: translational potential of systems genetics.

Genetics - 1 Oct 2009

Morozova Tatiana V, Ayroles Julien F, Jordan Katherine W, Duncan Laura H, Carbone Mary Anna, Lyman Richard F, Stone Eric A, Govindaraju Diddahally R, Ellison R Curtis, Mackay Trudy F C, Anholt Robert R H

Abstract excerpt

Identification of risk alleles for human behavioral disorders through genomewide association studies (GWAS) has been hampered by a daunting multiple testing problem. This problem can be circumvented for some phenotypes by combining genomewide studies in model organisms with subsequent candidate gene association analyses in human populations. Here, we characterized genetic networks that underlie the response to...

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Identifiers

PMID: 19652175
DOI: 10.1534/genetics.109.107490
PMCID: PMC2766331

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