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Article

ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.

Gastroenterology - 1 Jan 2010

Spirli Carlo, Okolicsanyi Stefano, Fiorotto Romina, Fabris Luca, Cadamuro Massimiliano, Lecchi Silvia, Tian Xin, Somlo Stefan, Strazzabosco Mario

Abstract excerpt

BACKGROUND & AIMS: Severe polycystic liver disease can complicate adult dominant polycystic kidney disease, a genetic disease caused by defects in polycystin-1 (Pkd1) or polycystin-2 (Pkd2). Liver cyst epithelial cells (LCECs) express vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2. We investigated the effects of VEGF on liver cyst growth and autocrine VEGF signaling in mice with Pkd1 and Pkd2...

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Identifiers

PMID: 19766642
DOI: 10.1053/j.gastro.2009.09.005
PMCID: PMC3000794

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PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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