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Article

Genetic polymorphisms of N-acetyltransferase 2 & susceptibility to antituberculosis drug-induced hepatotoxicity.

The Indian journal of medical research - 1 Dec 2016

Sharma Surendra K, Jha Brajesh Kumar, Sharma Abhishek, Sreenivas V, Upadhyay Vishwanath, Jaisinghani Chandrita, Singla Rohit, Mishra Hemant Kumar, Soneja Manish

Abstract excerpt

BACKGROUND & OBJECTIVES: The N-acetyltransferase 2 (NAT2) gene encodes an enzyme which both activates and deactivates arylamine and other drugs and carcinogens. This study was aimed to investigate the role of NAT2 gene polymorphism in anti-tuberculosis drug-induced hepatotoxicity (DIH). METHODS: In this prospective study, polymerase chain reaction-restriction fragment length polymorphism results for NAT2 gene...

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Identifiers

PMID: 28474630
DOI: 10.4103/ijmr.IJMR_684_14
PMCID: PMC5433286

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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