ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

doi:10.1164/rccm.201005-0701OC

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Article

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

American journal of respiratory and critical care medicine - 15 May 2011

Meyer Nuala J, Li Mingyao, Feng Rui, Bradfield Jonathan, Gallop Robert, Bellamy Scarlett, Fuchs Barry D, Lanken Paul N, Albelda Steven M, Rushefski Melanie, Aplenc Richard, Abramova Helen, Atochina-Vasserman Elena N, Beers Michael F, Calfee Carolyn S, Cohen Mitchell J, Pittet Jean-Francois, Christiani David C, O'Keefe Grant E, Ware Lorraine B, May Addison K, Wurfel Mark M, Hakonarson Hakon, Christie Jason D

Abstract excerpt

RATIONALE: Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI. OBJECTIVES: To identify ALI risk variants after major trauma using a large-scale candidate gene approach. METHODS: We performed a two-stage genetic association study. We derived findings in an African American cohort (n =...

Topics

Acute Lung Injury
Adult
Angiopoietin-2
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Odds Ratio

Polymorphism, Single Nucleotide

Protein Isoforms

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21257790
DOI: 10.1164/rccm.201005-0701OC
PMCID: PMC3114062

Genes

ANGPT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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