Article
Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.
PloS one - 1 Jan 2012
Christie Jason D, Wurfel Mark M, Feng Rui, O'Keefe Grant E, Bradfield Jonathan, Ware Lorraine B, Christiani David C, Calfee Carolyn S, Cohen Mitchell J, Matthay Michael, Meyer Nuala J, Kim Cecilia, Li Mingyao, Akey Joshua, Barnes Kathleen C, Sevransky Jonathan, Lanken Paul N, May Addison K, Aplenc Richard, Maloney James P, Hakonarson Hakon
Abstract excerpt
Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human Quad 610 BeadChip. We performed a two-stage GWA study...
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