Article
Genetic variation in the FAS gene and associations with acute lung injury.
American journal of respiratory and critical care medicine - 1 Feb 2011
Glavan Bradford J, Holden Tarah D, Goss Christopher H, Black R Anthony, Neff Margaret J, Nathens Avery B, Martin Thomas R, Wurfel Mark M
Abstract excerpt
RATIONALE: Fas (CD95) modulates apoptosis and inflammation and is believed to play an important role in lung injury. OBJECTIVES: To determine if common genetic variation in FAS is associated with acute lung injury (ALI) susceptibility, risk of death, and FAS gene expression. METHODS: We genotyped 14 single nucleotide polymorphisms (tagSNPS) in FAS in samples from healthy white volunteers (control subjects, n =...
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