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Article

Targets downstream of Cdk8 in Dictyostelium development.

BMC developmental biology - 21 Jan 2011

Greene David M, Bloomfield Gareth, Skelton Jason, Ivens Alasdair, Pears Catherine J

Abstract excerpt

BACKGROUND: Cdk8 is a component of the mediator complex which facilitates transcription by RNA polymerase II and has been shown to play an important role in development of Dictyostelium discoideum. This eukaryote feeds as single cells but starvation triggers the formation of a multicellular organism in response to extracellular pulses of cAMP and the eventual generation of spores. Strains in which the gene...

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PMID: 21255384
DOI: 10.1186/1471-213X-11-2
PMCID: PMC3037916

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