Article
Interleukin-28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection.
Hepatology (Baltimore, Md.) - 1 Jan 2011
Charlton Michael R, Thompson Alexander, Veldt Bart J, Watt Kym, Tillmann Hans, Poterucha John J, Heimbach Julie K, Goldstein David, McHutchison John
Abstract excerpt
UNLABELLED: Polymorphism in the interleukin-28B (IL28B) gene region, encoding interferon (IFN)-λ3, is strongly predictive of response to antiviral treatment in the nontransplant setting. We sought to determine the prevalence and impact on clinical outcomes of donor and recipient IL28B genotypes among liver transplant recipients. The cohort study included 189 consecutive patients infected with hepatitis C virus...
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