Article
p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.
Breast cancer research : BCR - 20 Jan 2011
Bourdon Jean-Christophe, Khoury Marie P, Diot Alexandra, Baker Lee, Fernandes Kenneth, Aoubala Mustapha, Quinlan Philip, Purdie Colin A, Jordan Lee B, Prats Anne-Catherine, Lane David P, Thompson Alastair M
Abstract excerpt
INTRODUCTION: Normal function of the p53 network is lost in most cancers, often through p53 mutation. The clinical impact of p53 mutations in breast cancer remains uncertain, especially where p53 isoforms may modify the effects of these p53 mutations. METHODS: Expression of p53β and p53γ isoforms, the isoforms identified in normal breast tissue, was detected by reverse transcription polymerase chain reaction from...
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