Article
TP53 drives invasion through expression of its Δ133p53β variant.
eLife - 15 Sept 2016
Gadea Gilles, Arsic Nikola, Fernandes Kenneth, Diot Alexandra, Joruiz Sébastien M, Abdallah Samer, Meuray Valerie, Vinot Stéphanie, Anguille Christelle, Remenyi Judit, Khoury Marie P, Quinlan Philip R, Purdie Colin A, Jordan Lee B, Fuller-Pace Frances V, de Toledo Marion, Cren Maïlys, Thompson Alastair M, Bourdon Jean-Christophe, Roux Pierre
Abstract excerpt
TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, based on clinical analysis corroborated with experimental data, that the p53 isoform Δ133p53β promotes cancer cell invasion, regardless of TP53 mutation status. Δ133p53β...
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