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Article

Cytoplasmic p53β Isoforms Are Associated with Worse Disease-Free Survival in Breast Cancer.

International journal of molecular sciences - 15 Jun 2022

Steffens Reinhardt Luiza, Groen Kira, Morten Brianna C, Bourdon Jean-Christophe, Avery-Kiejda Kelly A

Abstract excerpt

TP53 mutations are associated with tumour progression, resistance to therapy and poor prognosis. However, in breast cancer, TP53's overall mutation frequency is lower than expected (~25%), suggesting that other mechanisms may be responsible for the disruption of this critical tumour suppressor. p53 isoforms are known to enhance or disrupt p53 pathway activity in cell- and context-specific manners. Our previous...

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Identifiers

PMID: 35743117
DOI: 10.3390/ijms23126670
PMCID: PMC9223648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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