Article
High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma.
BMC cancer - 25 Jun 2018
Bischof Katharina, Knappskog Stian, Stefansson Ingunn, McCormack Emmet Martin, Trovik Jone, Werner Henrica Maria Johanna, Woie Kathrine, Gjertsen Bjorn Tore, Bjorge Line
Abstract excerpt
BACKGROUND: Uterine serous carcinoma (USC) is a rare but aggressive subtype of endometrial carcinoma. Large-scale comprehensive efforts have resulted in an improved molecular understanding of its pathogenesis, and the p53 pathway has been proposed as a key player and is potentially targetable. Here we attempt to further portray the p53 pathway in USC by assessing p53 isoform expression. METHODS: We applied...
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