The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.

doi:10.4049/jimmunol.1002402

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Article

The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2011

Carrol Enitan D, Payton Antony, Payne Deborah, Miyajima Fabio, Chaponda Mas, Mankhambo Limangeni A, Banda Daniel L, Molyneux Elizabeth M, Cox Helen, Jacobson Greg, Carr Daniel F, Molyneux Malcolm E, Stewart James P, Quinn John P, Hart C Anthony, Ollier William E

Abstract excerpt

IL-1R antagonist (IL-1Ra) is required for adequate host defense in invasive pneumococcal disease (IPD). The minor allele of an IL1RN gene (C/T) promoter polymorphism (rs4251961) has been shown to be associated with decreased IL-1Ra production in healthy adults. We genotyped 299 children with IPD, and examined 19 IL1RN haplotype-tagging single-nucleotide polymorphisms. Human embryonic kidney HEK293(T) cells were...

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PMID: 21248262
DOI: 10.4049/jimmunol.1002402

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