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Article

Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b–Regulated T Cell Functions

20 Jan 2011

Abstract excerpt

E3 ubiquitin ligases have been placed among the essential molecules involved in the regulation of T cell functions and T cell tolerance. However, it has never been experimentally proven in vivo whether these functions indeed depend on the catalytic E3 ligase activity. The Casitas B-cell lymphoma (Cbl) family protein Cbl-b was the first E3 ubiquitin ligase directly implicated in the activation and tolerance of the...

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PMID: 21248250
DOI: 10.4049/jimmunol.1003390

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