Article
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.
Molecular and cellular biology - 1 Jan 2006
van de Graaf Stan F J, Chang Qing, Mensenkamp Arjen R, Hoenderop Joost G J, Bindels René J M
Abstract excerpt
TRPV5 and TRPV6 are the most Ca2+-selective members of the transient receptor potential (TRP) family of cation channels and play a pivotal role in the maintenance of Ca2+ balance in the body. However, little is known about the mechanisms controlling the plasma membrane abundance of these channels to regulate epithelial Ca2+ transport. In this study, we demonstrated the direct and specific interaction of GDP-bound...
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