Article
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.
The Journal of biological chemistry - 25 Mar 2011
Pellissier Lucie P, Barthet Gaël, Gaven Florence, Cassier Elisabeth, Trinquet Eric, Pin Jean-Philippe, Marin Philippe, Dumuis Aline, Bockaert Joël, Banères Jean-Louis, Claeysen Sylvie
Abstract excerpt
The discovery that class C G protein-coupled receptors (GPCRs) function as obligatory dimeric entities has generated major interest in GPCR oligomerization. Oligomerization now appears to be a common feature among all GPCR classes. However, the functional significance of this process remains unclear because, in vitro, some monomeric GPCRs, such as rhodopsin and β(2)-adrenergic receptors, activate G proteins. By...
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