Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation.

The EMBO journal - 5 Jan 2011

Monnier Carine, Tu Haijun, Bourrier Emmanuel, Vol Claire, Lamarque Laurent, Trinquet Eric, Pin Jean-Philippe, Rondard Philippe

Abstract excerpt

Seven-transmembrane domain (7TM) receptors have important functions in cell-cell communication and can assemble into dimers or oligomers. Such complexes may allow specific functional cross-talk through trans-activation of interacting 7TMs, but this hypothesis requires further validation. Herein, we used the GABAB receptor, which is composed of two distinct subunits, GABAB1, which binds the agonist, and GABAB2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COS Cells

Share to Protein Multimerization

Share to Protein Structure, Tertiary

Share to Protein Subunits

Share to Receptors, GABA-B

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 21063387
DOI: 10.1038/emboj.2010.270
PMCID: PMC3020105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation.PMID 21063387Read ↗

Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex.Semantic proximity Read ↗

Partial agonism of taurine at gamma-containing native and recombinant GABAA receptors.Semantic proximity Read ↗

Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activationSemantic proximity Read ↗

Functional and structural basis of a negative allostery within GABAB hetero-tetramers.Semantic proximity Read ↗

A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism.Semantic proximity Read ↗

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.Semantic proximity Read ↗

Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.Semantic proximity Read ↗

Seven transmembrane receptors: something old, something new.Semantic proximity Read ↗

Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors.Semantic proximity Read ↗

Ligand-induced signal transduction within heterodimeric GABA(B) receptor.Semantic proximity Read ↗

The desensitization pathway of GABAA receptors, one subunit at a time.Semantic proximity Read ↗

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.