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Article

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation

17 Jan 2011

Abstract excerpt

Ikaros is associated with both gene transcriptional activation and repression in lymphocytes. Ikaros acts also as repressor of human γ-globin (huγ-) gene transcription in fetal and adult erythroid cells. Whether and eventually, how Ikaros can function as a transcriptional activator in erythroid cells remains poorly understood. Results presented herein demonstrate that Ikaros is a developmental-specific activator...

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PMID: 21245044
DOI: 10.1093/nar/gkq1271

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