Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of Ikaros in human erythroid differentiation.

Blood - 1 Feb 2008

Dijon Marilyne, Bardin Florence, Murati Anne, Batoz Michèle, Chabannon Christian, Tonnelle Cécile

Abstract excerpt

Ikaros--a factor that positively or negatively controls gene transcription--is active in murine adult erythroid cells, and involved in fetal to adult globin switching. Mice with Ikaros mutations have defects in erythropoiesis and anemia. In this paper, we have studied the role of Ikaros in human erythroid development for the first time. Using a gene-transfer strategy, we expressed Ikaros 6 (Ik6)--a known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cytokines
Share to Erythroid Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erythropoiesis

Share to Fetal Blood

Share to Globins

Share to Ikaros Transcription Factor

Share to Myelopoiesis

Source

Identifiers

PMID: 17934067
DOI: 10.1182/blood-2007-07-098202

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of Ikaros in human erythroid differentiation.PMID 17934067Read ↗

A Dominant-Negative Isoform of IKAROS Expands Primitive Normal Human Hematopoietic CellsSemantic proximity Read ↗

Ikaros Isoform X Is Selectively Expressed in Myeloid DifferentiationSemantic proximity Read ↗

Regulator of myeloid differentiation and function: The secret life of IkarosSemantic proximity Read ↗

Cutting Edge: Predominant Expression of a Novel Ikaros Isoform in Normal Human HemopoiesisSemantic proximity Read ↗

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongationSemantic proximity Read ↗

Multiple hematopoietic defects and delayed globin switching in Ikaros null miceSemantic proximity Read ↗

Defects in hemopoietic stem cell activity in Ikaros mutant mice.Semantic proximity Read ↗

Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.Semantic proximity Read ↗

Ikaros gene expression and leukemia.Semantic proximity Read ↗

The role of the Ikaros gene in lymphocyte development and homeostasis.Semantic proximity Read ↗

Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cellsSemantic proximity Read ↗

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.