Article
Wnt signaling is regulated by endoplasmic reticulum retention.
PloS one - 10 Jul 2009
Zoltewicz J Susie, Ashique Amir M, Choe Youngshik, Lee Gena, Taylor Stacy, Phamluong Khanhky, Solloway Mark, Peterson Andrew S
Abstract excerpt
Precise regulation of Wnt signaling is important in many contexts, as in development of the vertebrate forebrain, where excessive or ectopic Wnt signaling leads to severe brain defects. Mutation of the widely expressed oto gene causes loss of the anterior forebrain during mouse embryogenesis. Here we report that oto is the mouse ortholog of the gpi deacylase gene pgap1, and that the endoplasmic reticulum...
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