Article
Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.
Developmental cell - 1 Feb 2006
Miura Grant I, Buglino John, Alvarado Diego, Lemmon Mark A, Resh Marilyn D, Treisman Jessica E
Abstract excerpt
Lipid modifications such as palmitoylation or myristoylation target intracellular proteins to cell membranes. Secreted ligands of the Hedgehog and Wnt families are also palmitoylated; this modification, which requires the related transmembrane acyltransferases Rasp and Porcupine, can enhance their secretion, transport, or activity. We show here that rasp is also essential for the developmental functions of Spitz,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.