Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.

The Journal of biological chemistry - 19 Jun 2015

Wang Wei, Runkle Kristin B, Terkowski Samantha M, Ekaireb Rachel I, Witze Eric S

Abstract excerpt

Wnt5a signaling regulates polarized cell behavior, but the downstream signaling events that promote cell polarity are not well understood. Our results show that Wnt5a promotes depalmitoylation of the melanoma cell adhesion molecule (MCAM) at cysteine 590. Mutation of Cys-590 to glycine is sufficient to polarize MCAM localization, similar to what is observed with Wnt5a stimulation. Inhibition of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipoylation
Share to Neoplasm Invasiveness
Share to Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Processing, Post-Translational

Share to Proto-Oncogene Proteins

Share to Thiolester Hydrolases

Share to Wnt-5a Protein

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25944911
DOI: 10.1074/jbc.M115.639609
PMCID: PMC4505481

Genes

MCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.PMID 25944911Read ↗

Palmitoylation of proteins in cancer.Semantic proximity Read ↗

Mutations in the Drosophila tricellular junction protein M6 synergize with RasV12 to induce apical cell delamination and invasion.Semantic proximity Read ↗

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.Semantic proximity Read ↗

The serine/threonine kinase MINK1 directly regulates the function of promigratory proteinsSemantic proximity Read ↗

Mgat4b mediated selective <i>N</i> -glycosylation regulates melanocyte development and melanoma progressionSemantic proximity Read ↗

ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradationSemantic proximity Read ↗

CD151—A Striking Marker for Cancer TherapySemantic proximity Read ↗

Tumor Protein D54 (TPD54) regulates intracellular protein trafficking, cellular function and disease progression in melanomaSemantic proximity Read ↗

Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanomaSemantic proximity Read ↗

Fatty acylation of Wnt proteins.Semantic proximity Read ↗

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.Semantic proximity Read ↗

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell MotilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.