Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

doi:10.1002/dvg.22398

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Article

Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

Genesis (New York, N.Y. : 2000) - 1 Jul 2013

Ryder Edward, Wong Kim, Gleeson Diane, Keane Thomas M, Sethi Debarati, Vyas Sapna, Wardle-Jones Hannah, Bussell James N, Houghton Richard, Salisbury Jennifer, Harvey Nina, Adams David J, Ramirez-Solis Ramiro

Abstract excerpt

We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other...

Topics

Albinism
Animals
Genome
Genomics
Genotype
Mice
Mice, Inbred C57BL
Mice, Transgenic
Monophenol Monooxygenase
Sequence Analysis, DNA

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Identifiers

PMID: 23620107
DOI: 10.1002/dvg.22398
PMCID: PMC3799019

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