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Article

Evidence for the presence of a critical disulfide bond in the mouse EP3γ receptor.

Prostaglandins & other lipid mediators - 1 Feb 2011

Downey Jason D, Sanders Charles R, Breyer Richard M

Abstract excerpt

To determine the contribution of cysteines to the function of the mouse E-prostanoid subtype 3 gamma (mEP3γ), we tested a series of cysteine-to-alanine mutants. Two of these mutants, C107A and C184A, showed no agonist-dependent activation in a cell-based reporter assay for mEP3γ, whereas none of the other cysteine-to-alanine mutations disrupted mEP3γ signal transduction. Total cell membranes prepared from HEK293...

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Identifiers

PMID: 21236356
DOI: 10.1016/j.prostaglandins.2010.12.007
PMCID: PMC3065360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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