Article
Immunoglobulin E-binding site in Fc epsilon receptor (Fc epsilon RII/CD23) identified by homolog-scanning mutagenesis.
The Journal of biological chemistry - 5 Jan 1992
Bettler B, Texido G, Raggini S, Rüegg D, Hofstetter H
Abstract excerpt
The IgE-binding site of the human low-affinity receptor for IgE (Fc epsilon RII/CD23) has previously been mapped to the extracellular domain between amino acid residues 160 and 287. We now have investigated which conformational epitope within this domain specifies the receptor-ligand interaction....
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antigens, Differentiation, B-Lymphocyte
- Base Sequence
- Binding Sites
- Blotting, Western
- Cysteine
- Disulfides
- Humans
- Immunoglobulin E
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Protein Conformation
- Receptors, Fc
- Receptors, IgE
- Sequence Homology, Nucleic Acid
- Serine