Quinidine-enhanced beta-blockade during treatment with propafenone in extensive metabolizer human subjects.

doi:10.1038/clpt.1994.6

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Article

Quinidine-enhanced beta-blockade during treatment with propafenone in extensive metabolizer human subjects.

Clinical pharmacology and therapeutics - 1 Jan 1994

Mörike K E, Roden D M

Abstract excerpt

Propafenone, a sodium channel blocking antiarrhythmic drug with beta-blocking properties, is metabolized to non-beta-blocking metabolites in part by cytochrome P4502D6. Subtherapeutic doses of quinidine inhibit P4502D6 and increase plasma propafenone in extensive metabolizer subjects, in whom the...

Topics

Adrenergic beta-Antagonists
Adult
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Double-Blind Method
Drug Synergism
Exercise
Female
Heart Rate
Humans
Isoproterenol
Male
Mixed Function Oxygenases
Phenotype
Propafenone
Quinidine
Stereoisomerism

Source

Open in PubMed

Identifiers

PMID: 7905369
DOI: 10.1038/clpt.1994.6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7905369-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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