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Article

MDM2 promoter SNP309 is associated with risk of occurrence and advanced lymph node metastasis of nasopharyngeal carcinoma in Chinese population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2007

Zhou Gangqiao, Zhai Yun, Cui Ying, Zhang Xiumei, Dong Xiaojia, Yang Hao, He Ying, Yao Kaitai, Zhang Hongxing, Zhi Lianteng, Yuan Xiaoyan, Qiu Wei, Zhang Xiaoai, Shen Yan, Qiang Boqing, He Fuchu

Abstract excerpt

PURPOSE: Mouse double minute 2 (MDM2) is a key negative regulator of the p53 activity. Recently, a polymorphism in the MDM2 intronic promoter, SNP309, was shown to influence MDM2 expression and p53 activity. We examined whether the SNP309 was related to the risk of developing nasopharyngeal carcinoma (NPC) among Chinese populations. EXPERIMENTAL DESIGN: We genotyped the SNP309 in two independent case-control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17473193
DOI: 10.1158/1078-0432.CCR-06-2281

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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