Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin.

Cell cycle (Georgetown, Tex.) - 15 Jan 2011

Kepkay Rosemarie, Attwood Kathleen M, Ziv Yael, Shiloh Yosef, Dellaire Graham

Abstract excerpt

The promyelocytic leukemia (PML) protein is the main structural component of subnuclear domains termed PML nuclear bodies (PML NBs), which are implicated in tumor suppression by regulating apoptosis, cell senescence, and DNA repair. Previously, we demonstrated that ATM kinase can regulate changes in PML NB number in response to DNA double-strand breaks (DSBs). PML NBs make extensive contacts with chromatin and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Histones

Share to Promyelocytic Leukemia Protein

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 21228624
DOI: 10.4161/cc.10.2.14551

Genes

PML
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin.PMID 21228624Read ↗

PML nuclear bodies: regulation, function and therapeutic perspectivesSemantic proximity Read ↗

The function, regulation and therapeutic implications of the tumor suppressor protein, PMLSemantic proximity Read ↗

The PML hub: An emerging actor of leukemia therapiesSemantic proximity Read ↗

Functional Connection between Rad51 and PML in Homology-Directed RepairSemantic proximity Read ↗

PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replicationSemantic proximity Read ↗

The functional roles of PML nuclear bodies in genome maintenanceSemantic proximity Read ↗

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.Semantic proximity Read ↗

The Tumor Suppressor PML Specifically Accumulates at RPA/Rad51-Containing DNA Damage Repair Foci but Is Nonessential for DNA Damage-Induced Fibroblast SenescenceSemantic proximity Read ↗

PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damageSemantic proximity Read ↗

Regulation of p53 activity in nuclear bodies by a specific PML isoformSemantic proximity Read ↗

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4Semantic proximity Read ↗

PML nuclear body disruption impairs DNA double-strand break sensing and repair in APLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.