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Article

Structural basis of improved second-generation 3-nitro-tyrosine tRNA synthetases.

Biochemistry - 1 Apr 2014

Cooley Richard B, Feldman Jessica L, Driggers Camden M, Bundy Taylor A, Stokes Audrey L, Karplus P Andrew, Mehl Ryan A

Abstract excerpt

Genetic code expansion has provided the ability to site-specifically incorporate a multitude of noncanonical amino acids (ncAAs) into proteins for a wide variety of applications, but low ncAA incorporation efficiency can hamper the utility of this powerful technology. When investigating proteins containing the post-translational modification 3-nitro-tyrosine (nitroTyr), we developed second-generation amino-acyl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24611875
DOI: 10.1021/bi5001239
PMCID: PMC3985459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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