Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects.

Human molecular genetics - 1 Sept 2010

Bentham Jamie, Michell Anna C, Lockstone Helen, Andrew Daniel, Schneider Jürgen E, Brown Nigel A, Bhattacharya Shoumo

Abstract excerpt

Deficiency of the transcription factor Cited2 in mice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially penetrant cardiopulmonary laterality defects resulting from an abnormal Nodal->Pitx2c pathway. Here we show that a maternal high-fat diet more than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Dietary Fats
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeobox Protein PITX2

Share to Homeodomain Proteins

Share to Maternal-Fetal Exchange

Share to Repressor Proteins

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 20566713
DOI: 10.1093/hmg/ddq251
PMCID: PMC2916708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20566713-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects.PMID 20566713Read ↗

Loss of Cited2 causes congenital heart disease by perturbing left–right patterning of the body axisSemantic proximity Read ↗

Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency.Semantic proximity Read ↗

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs.Semantic proximity Read ↗

NPHP4 variants are associated with pleiotropic heart malformations.Semantic proximity Read ↗

CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expressionSemantic proximity Read ↗

The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver diseaseSemantic proximity Read ↗

Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasia.Semantic proximity Read ↗

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.Semantic proximity Read ↗

The Role of Pitx2 during Cardiac Development Linking Left–Right Signaling and Congenital Heart DiseasesSemantic proximity Read ↗

Regulation of left-right asymmetry by thresholds of Pitx2c activity.Semantic proximity Read ↗

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2Semantic proximity Read ↗

The Long Noncoding RNA <i>Playrr</i> Regulates <i>Pitx2</i> Dosage and Protects Against Cardiac ArrhythmiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.