Article
Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours.
Virchows Archiv : an international journal of pathology - 1 Jul 2011
Juhlin C Christofer, Haglund Felix, Obara Takao, Arnold Andrew, Larsson Catharina, Höög Anders
Abstract excerpt
Hyperparathyroidism 2 (HRPT2) gene mutations underlie hereditary and sporadic forms of primary hyperparathyroidism (PHPT), and the encoded product parafibromin has been established as a marker for facilitating parathyroid tumour classification. HRPT2 mutations and reduced nuclear expression of parafibromin are readily observed in parathyroid carcinomas but rarely in benign tumours, thereby aiding the...
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