Article
Immunohistochemical assessment of parafibromin in mouse and human tissues.
Journal of anatomy - 1 Dec 2006
Porzionato Andrea, Macchi Veronica, Barzon Luisa, Masi Giulia, Iacobone Maurizio, Parenti Anna, Palù Giorgio, De Caro Raffaele
Abstract excerpt
Parafibromin is a protein encoded by the HRPT2 oncosuppressor gene, whose mutation causes the hyperparathyroidism-jaw tumour syndrome, characterized by the occurrence of parathyroid adenoma or carcinoma, fibro-osseous jaw tumours, and renal neoplastic and non-neoplastic abnormalities. Non-morphological techniques, such as Northern and Western blotting and reverse transcriptase-PCR, indicate that parafibromin is...
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