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Article

Parafibromin inhibits cancer cell growth and causes G1 phase arrest.

Biochemical and biophysical research communications - 10 Nov 2006

Zhang Chun, Kong Dong, Tan Min-Han, Pappas Donald L, Wang Peng-Fei, Chen Jindong, Farber Leslie, Zhang Nian, Koo Han-Mo, Weinreich Michael, Williams Bart O, Teh Bin Tean

Abstract excerpt

The HRPT2 (hereditary hyperparathyroidism type 2) tumor suppressor gene encodes a ubiquitously expressed 531 amino acid protein termed parafibromin. Inactivation of parafibromin predisposes one to the development of HPT-JT syndrome. To date, the role of parafibromin in tumorigenesis is largely unknown. Here, we report that parafibromin is a nuclear protein that possesses anti-proliferative properties. We show...

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Identifiers

PMID: 16989776
DOI: 10.1016/j.bbrc.2006.08.169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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