CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort.

doi:10.1007/s13402-012-0100-x

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Article

CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort.

Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2012

Guarnieri Vito, Battista Claudia, Muscarella Lucia Anna, Bisceglia Michele, de Martino Danilo, Baorda Filomena, Maiello Evaristo, D'Agruma Leonardo, Chiodini Iacopo, Clemente Celeste, Minisola Salvatore, Romagnoli Elisabetta, Corbetta Sabrina, Viti Raffaella, Eller-Vainicher Cristina, Spada Anna, Iacobellis Michela, Malavolta Nazzarena, Carella Massimo, Canaff Lucie, Hendy Geoffrey N, Cole David E C, Scillitani Alfredo

Abstract excerpt

OBJECTIVE: To determine if molecular and immunohistochemical (IHC) features of the HRPT2/CDC73 gene and its product, parafibromin, predict the natural history of parathyroid malignancy, particularly atypical adenoma, as seen in a single-centre patient cohort. METHODS: Matched tumor and non-tumor tissues were obtained from 46 patients with parathyroid carcinoma (CA) (n = 15), atypical adenoma (AA) (n = 14) and...

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PMID: 22987117
DOI: 10.1007/s13402-012-0100-x
PMCID: PMC12995092

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CDC73

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